6-O-Methyloxaline, Meleagrine
MELEAGRIN
CAS: 71751-77-4
Molecular Formula: C23H23N5O4
6-O-Methyloxaline, Meleagrine - Names and Identifiers
| Name | MELEAGRIN |
| Synonyms | MELEAGRIN Meleagrine 6-O-Methyloxaline, Meleagrine |
| CAS | 71751-77-4 |
| EINECS | 604-604-1 |
6-O-Methyloxaline, Meleagrine - Physico-chemical Properties
| Molecular Formula | C23H23N5O4 |
| Molar Mass | 433.46 |
| Melting Point | >165oC |
| Solubility | Soluble in DMSO (up to 10 mg/ml) |
| Appearance | Yellow oil. |
| Color | Tan |
| Storage Condition | -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| In vitro study | Meleagrin inhibits the growth of the human breast cancer cell lines MDA-MB-231, MDA-468, BT-474, SK BR-3, MCF7 and MCF7-dox. Meleagrin causes a dose-dependent inhibition of HGF-induced cell migration, and invasion of breast cancer cell lines. |
| In vivo study | Meleagrin potently suppresses the invasive triple negative breast tumor cell growth in an orthotopic athymic nude mice model. |
6-O-Methyloxaline, Meleagrine - Reference Information
| biological activity | Meleagri is composed fungal-derived alkaloids of roquetiapine C with antimicrobial and antiproliferative activity. Meleagrin is a class of FabI inhibitors. Meleagri is a major c-Met inhibitory entity that helps control c-Met-dependent metastatic and invasive breast cancer. |
Last Update：2024-04-10 22:29:15
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